' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 15 Reviews
8.6
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Calories
<5
Total Carbohydrate
<1 g
<1%**
Total Sugars
0 g
†
Includes 0 g Added Sugars
0%**
Xylitol
<1 g
†
Vitamin C (as Ascorbic Acid)
100 mg
111%
Zinc (elemental) (from 15 mg Zinc Bisglycinate) (TRAACS™)
3 mg
27%
Elderberry (10:1 Concentrate)(Sambucus nigra) (Fruit)
150 mg
†
Top Medical Research Studies
9
Zinc counters heart cell injury
Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation.
Highly relevant to cardiovascular health
We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Read More
9
Elderberry infusion boosts heart health
Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after Sambucus ebulus L. fruit infusion consumption.
Strong relevance to cardiovascular effects
We explored the impact of Sambucus ebulus L. (elderberry) fruit infusion on cardiovascular health by examining its effects on body weight, blood pressure, blood sugar, and lipid profiles in 21 healthy volunteers aged 20 to 59. Each participant consumed 200 ml of elderberry infusion daily for 30 days, allowing us to measure changes in their health markers.
After the intervention period, we observed notable improvements in key health indicators. There was a significant reduction in triglycerides by 14.92%, total cholesterol by 15.04%, and LDL cholesterol by 24.67%. Additionally, the ratio of HDL to LDL cholesterol increased by 42.77%, indicating a healthier lipid profile.
We also noted enhancements in serum antioxidant capacity and total thiol levels. This first human study on the effects of elderberry fruit infusion suggests promising potential for improving cardiovascular health and addressing oxidative stress-related issues. Overall, the findings indicate that incorporating elderberry into our diet could be beneficial for heart health.
After the intervention period, we observed notable improvements in key health indicators. There was a significant reduction in triglycerides by 14.92%, total cholesterol by 15.04%, and LDL cholesterol by 24.67%. Additionally, the ratio of HDL to LDL cholesterol increased by 42.77%, indicating a healthier lipid profile.
We also noted enhancements in serum antioxidant capacity and total thiol levels. This first human study on the effects of elderberry fruit infusion suggests promising potential for improving cardiovascular health and addressing oxidative stress-related issues. Overall, the findings indicate that incorporating elderberry into our diet could be beneficial for heart health.
Read More
8
Elderberry aids cardiovascular health
Anti-cytokine therapy for prevention of atherosclerosis.
Direct relevance to heart disease
We explored the potential of elderberry as a natural treatment for cardiovascular disease, particularly in preventing atherosclerosis. A recent study employed a carefully designed method, including a two-year double-blind, placebo-controlled clinical trial that focused on the effects of a herbal preparation named "Inflaminat." This preparation features elderberry along with other natural components known for their anti-inflammatory properties.
The findings revealed that "Inflaminat" significantly reduced the progression of carotid intima-media thickness (IMT), which is a key marker for atherosclerosis. This suggests that elderberry, along with its herbal companions, could play an important role in managing heart health by combating inflammation—a major factor in the development of atherosclerotic lesions.
Overall, our review indicates that using elderberry in conjunction with other natural herbs is promising for reducing cardiovascular risks. With no significant side effects noted, this herbal approach provides a valuable option for long-term prevention of heart-related issues.
The findings revealed that "Inflaminat" significantly reduced the progression of carotid intima-media thickness (IMT), which is a key marker for atherosclerosis. This suggests that elderberry, along with its herbal companions, could play an important role in managing heart health by combating inflammation—a major factor in the development of atherosclerotic lesions.
Overall, our review indicates that using elderberry in conjunction with other natural herbs is promising for reducing cardiovascular risks. With no significant side effects noted, this herbal approach provides a valuable option for long-term prevention of heart-related issues.
Read More
Most Useful Reviews
9.5
Effective complex
This SUPER COMPLEX has significantly boosted my immunity. The combination of zinc, vitamin C, and elderberry is remarkable. I've found that increasing the dosage at the first sign of a cold leads to noticeable relief often within a day. I consistently take them for both myself and my parents, and I appreciate the convenience of needing only one tablet per day for prevention.
Read More
9.5
Prevention success
This complex is superb during cold season. Combining elderberry, zinc, and vitamin C provides a strong antiviral effect. Starting treatment promptly with these lozenges can avert colds and their complications. My son remains antibiotic-free thanks to timely vitamin administration.
Read More
8.8
Effective prevention
Elderberry and vitamin C lozenges have been effective at the first signs of a cold. If taken promptly, they assist the body in coping with the disease and prevent full-blown illness. They also contain zinc and have a pleasant sour taste.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
Vitamin C may lower blood pressure
Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial.
Moderate relevance to cardiovascular research.
We conducted a study to evaluate the effects of a vitamin C supplement combined with a hawthorn beverage on blood pressure and oxidative stress among workers exposed to heat. This involved a 40-day cluster-randomized controlled trial where participants were split into two groups: one received the vitamin C and hawthorn drink, while the other was provided with slightly salted water.
Throughout the study, we measured blood pressure and levels of a specific oxidative stress marker at different intervals. Notably, we observed significant reductions in both systolic and diastolic blood pressure among those who consumed the vitamin C and hawthorn beverage compared to the control group. This suggests that the combination may help manage elevated blood pressure linked to heat exposure.
The findings highlight the potential role of vitamin C, especially when paired with other beneficial compounds in the hawthorn beverage, in combating oxidative stress and promoting cardiovascular health in individuals working in challenging environmental conditions.
Throughout the study, we measured blood pressure and levels of a specific oxidative stress marker at different intervals. Notably, we observed significant reductions in both systolic and diastolic blood pressure among those who consumed the vitamin C and hawthorn beverage compared to the control group. This suggests that the combination may help manage elevated blood pressure linked to heat exposure.
The findings highlight the potential role of vitamin C, especially when paired with other beneficial compounds in the hawthorn beverage, in combating oxidative stress and promoting cardiovascular health in individuals working in challenging environmental conditions.
Read More
9
Zinc nanoparticles reduce heart damage
Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.
Moderate relevance to cardiovascular research
We focused our research on how zinc oxide nanoparticles (ZnONPs) might help reduce heart damage caused by cisplatin, a well-known chemotherapy drug. In this study, we used rats divided into different groups, some receiving varying doses of ZnONPs and others serving as control groups.
Our findings indicated that as the dosage of ZnONPs increased up to 50 mg/kg, there was a marked improvement in cardiovascular markers. We observed reduced levels of oxidative stress, inflammation, and cell damage in the heart tissues of those treated with ZnONPs. More specifically, measures related to heart tissue health and serum biomarkers showed that rats receiving higher doses exhibited recovery similar to that of healthy rats.
Overall, we concluded that ZnONPs serve as a protective agent against cisplatin-induced cardiotoxicity, showcasing their potential in improving heart health during cancer treatment.
Our findings indicated that as the dosage of ZnONPs increased up to 50 mg/kg, there was a marked improvement in cardiovascular markers. We observed reduced levels of oxidative stress, inflammation, and cell damage in the heart tissues of those treated with ZnONPs. More specifically, measures related to heart tissue health and serum biomarkers showed that rats receiving higher doses exhibited recovery similar to that of healthy rats.
Overall, we concluded that ZnONPs serve as a protective agent against cisplatin-induced cardiotoxicity, showcasing their potential in improving heart health during cancer treatment.
Read More
9
Zinc counters heart cell injury
Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation.
Highly relevant to cardiovascular health
We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Read More
9
Elderberry infusion boosts heart health
Improved lipid profile and increased serum antioxidant capacity in healthy volunteers after Sambucus ebulus L. fruit infusion consumption.
Strong relevance to cardiovascular effects
We explored the impact of Sambucus ebulus L. (elderberry) fruit infusion on cardiovascular health by examining its effects on body weight, blood pressure, blood sugar, and lipid profiles in 21 healthy volunteers aged 20 to 59. Each participant consumed 200 ml of elderberry infusion daily for 30 days, allowing us to measure changes in their health markers.
After the intervention period, we observed notable improvements in key health indicators. There was a significant reduction in triglycerides by 14.92%, total cholesterol by 15.04%, and LDL cholesterol by 24.67%. Additionally, the ratio of HDL to LDL cholesterol increased by 42.77%, indicating a healthier lipid profile.
We also noted enhancements in serum antioxidant capacity and total thiol levels. This first human study on the effects of elderberry fruit infusion suggests promising potential for improving cardiovascular health and addressing oxidative stress-related issues. Overall, the findings indicate that incorporating elderberry into our diet could be beneficial for heart health.
After the intervention period, we observed notable improvements in key health indicators. There was a significant reduction in triglycerides by 14.92%, total cholesterol by 15.04%, and LDL cholesterol by 24.67%. Additionally, the ratio of HDL to LDL cholesterol increased by 42.77%, indicating a healthier lipid profile.
We also noted enhancements in serum antioxidant capacity and total thiol levels. This first human study on the effects of elderberry fruit infusion suggests promising potential for improving cardiovascular health and addressing oxidative stress-related issues. Overall, the findings indicate that incorporating elderberry into our diet could be beneficial for heart health.
Read More
8
Antioxidants show promise for FGR
The Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review.
Lower relevance due to context
This systematic review focused on the potential effects of antioxidants, particularly vitamin C, on cardiovascular health in cases of fetal growth restriction (FGR). We assessed various studies that examined how these treatments might enhance cardiac and vascular outcomes in affected individuals.
Our exploration revealed that a majority of the studies indicated some level of cardiovascular protection following antioxidant intervention. Specifically, 71% of the studies noted improvements in at least one of the cardiac or vascular parameters in growth-restricted offspring. Vitamin C, along with other antioxidants, was highlighted as part of several approaches to reduce oxidative stress, which is known to contribute to cardiovascular issues.
However, it's essential to note that the specific impact of vitamin C alone was not extensively distinguished from its combined effects with other antioxidants. This ambiguity makes it challenging to pin down its isolated benefits.
Overall, while antioxidant treatments present a promising avenue for addressing cardiovascular deficits associated with FGR, crucial gaps in research remain, preventing us from determining the most effective strategies for clinical use.
Our exploration revealed that a majority of the studies indicated some level of cardiovascular protection following antioxidant intervention. Specifically, 71% of the studies noted improvements in at least one of the cardiac or vascular parameters in growth-restricted offspring. Vitamin C, along with other antioxidants, was highlighted as part of several approaches to reduce oxidative stress, which is known to contribute to cardiovascular issues.
However, it's essential to note that the specific impact of vitamin C alone was not extensively distinguished from its combined effects with other antioxidants. This ambiguity makes it challenging to pin down its isolated benefits.
Overall, while antioxidant treatments present a promising avenue for addressing cardiovascular deficits associated with FGR, crucial gaps in research remain, preventing us from determining the most effective strategies for clinical use.
Read More
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Effective complex
This SUPER COMPLEX has significantly boosted my immunity. The combination of zinc, vitamin C, and elderberry is remarkable. I've found that increasing the dosage at the first sign of a cold leads to noticeable relief often within a day. I consistently take them for both myself and my parents, and I appreciate the convenience of needing only one tablet per day for prevention.
Read More
9.5
Prevention success
This complex is superb during cold season. Combining elderberry, zinc, and vitamin C provides a strong antiviral effect. Starting treatment promptly with these lozenges can avert colds and their complications. My son remains antibiotic-free thanks to timely vitamin administration.
8.8
Effective prevention
Elderberry and vitamin C lozenges have been effective at the first signs of a cold. If taken promptly, they assist the body in coping with the disease and prevent full-blown illness. They also contain zinc and have a pleasant sour taste.
9.5
Avoided complications
This high-quality antiviral complex of Elderberry, Zinc, and Vitamin C has a remarkable antiviral effect. If you take it at the first signs of a cold, you can avoid the disease and its complications. My son, who is only 5, has never needed antibiotics due to my timely provision of vitamins. This complex is a lifesaver.
Read More
8.8
Cold relief
I take zinc with vitamin C and elderberry at the first sign of illness. It effectively reduces the duration of the cold, making it easier to manage. The natural composition is beneficial, and I appreciate the company for producing effective additives. I have not experienced any side effects, and my stomach responds well to it.
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